Below is a list of key publications enabled by the CHARM Consortium:
Farncombe et al. (2026). Non-invasive screening in hereditary cancer: A randomized controlled trial to test cell-free DNA-based early detection in the CHARM consortium
Farncombe, K. M., Sobotka, J. A., Aronson, M., Basik, M., Bombard, Y., Born, L., Cheifetz, R., Clausen, M., Coburn, N., Dawson, L., Doria, A. S., Elbanna, K. Y., Etchegary, H., Foulkes, W. D., Hessels, C., Hyde, A., Kazazian, K., Kinnaird, A., Koch, C. A., Laframboise, S., Lerner-Ellis, J., Lheureux, S., Malkin, D., Metser, U., Penney, L. S., Ridd, S., Schrader, K. A., Tiano, T., Tone, A. A., Veit-Haibach, P., Wong, S., Xu, W., Pugh, T. J., & Kim, R. H.
European Journal of Human Genetics. https://doi.org/10.1038/s41431-026-02014-z
Ensminger et al. (2025). Early cancer detection in hereditary breast and ovarian cancer syndrome with cell-free DNA
Ensminger, E., Luo, P., Sobotka, J. A., Wong, D., Prokopec, S. D., Bruce, J. P., Danesh, A., Eagles, J., Oldfield, L., Pederson, S., Farncombe, K. M., Purnaghshband, H., Aguilar-Mahecha, A., Nand, A., Lujan Toro, B. E., Heisler, L. E., Lam, B., Veit-Haibach, P., Lupien, M., Basik, M., Kim, R. H., Pugh, T., & CHARM Consortium.
medRivX. https://doi.org/10.64898/2025.12.03.25340892
Terry Fox Research Institute Marathon of Hope Cancer Centers Network (2025). The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative
Terry Fox Research Institute Marathon of Hope Cancer Centers Network.
Cancer Cell. https://doi.org/10.1016/j.ccell.2025.03.014
Wong et al. (2024). Cell-free DNA from germline TP53 mutation carriers reflect cancer-like fragmentation patterns
Wong, D., Tageldein, M., Luo, P., Ensminger, E., Bruce, J., Oldfield, L., Gong, H., Fischer, N. W., Laverty, B., Subasri, V., Davidson, S., Khan, R., Villani, A., Shlien, A., Kim, R. H., Malkin, D., & Pugh, T. J.
Nature Communications. https://doi.org/10.1038/s41467-024-51529-w
Wong et al. (2024). Early cancer detection in Li–Fraumeni syndrome with cell-free DNA
Wong, D., Luo, P., Oldfield, L. E., Gong, H., Brunga, L., Rabinowicz, R., Subasri, V., Chan, C., Downs, T., Farncombe, K. M., Luu, B., Norman, M., Sobotka, J. A., Uju, P., Eagles, J., Pedersen, S., Wellum, J., Danesh, A., Prokopec, S. D., Stutheit-Zhao, E. Y., Znassi, N., Heisler, L. E., Jovelin, R., Lam, B., Lujan Toro, B. E., Marsh, K., Sundaravadanam, Y., Torti, D., Man, C., Goldenberg, A., Xu, W., Veit-Haibach, P., Doria, A. S., Malkin, D., Kim, R. H., & Pugh, T. J.
Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-23-0456
Farncombe et al. (2023).Current and new frontiers in hereditary cancer surveillance: Opportunities for liquid biopsy
Farncombe, K. M., Wong, D., Norman, M. L., Oldfield, L. E., Sobotka, J. A., Basik, M., Bombard, Y., Carile, V., Dawson, L., Foulkes, W. D., Malkin, D., Karsan, A., Parkin, P., Penney, L. S., Pollett, A., Schrader, K. A., Pugh, T. J., Kim, R. H., & CHARM Consortium.
American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2023.08.014
Adi-Wauran et al. (2023).“I just wanted more”: Hereditary cancer syndromes patients’ perspectives on the utility of circulating tumour DNA testing for cancer screening
Adi-Wauran, E., Clausen, M., Shickh, S., Gagliardi, A. R., Denburg, A., Oldfield, L. E., Sam, J., Reble, E., Krishnapillai, S., Regier, D. A., Baxter, N. N., Dawson, L., Penney, L. S., Foulkes, W., Basik, M., Sun, S., Schrader, K. A., Karsan, A., Pollett, A., Pugh, T. J., Kim, R. H., & Bombard, Y.
European Journal of Human Genetics. https://doi.org/10.1038/s41431-023-01473-y
Shickh et al. (2022).“Game changer”: Health professionals’ views on the clinical utility of circulating tumor DNA testing in hereditary cancer syndrome management
Shickh, S., Oldfield, L. E., Clausen, M., Mighton, C., Sebastian, A., Calvo, A., Baxter, N. N., Dawson, L., Penney, L. S., Foulkes, W., Basik, M., Sun, S., Schrader, K. A., Regier, D. A., Karsan, A., Pollett, A., Pugh, T. J., Kim, R. H., Bombard, Y., & CHARM Consortium.
The Oncologist. https://doi.org/10.1093/oncolo/oyac039